Guest Houses & Vacation Rentals in St. Charles, MO

Enjoy the privacy and comfort of a rental house on your next trip to St. Charles. Guest houses are available in the middle of the action of Historic Main Street, amid the charm of Frenchtown, tucked in the rolling hills of Historic Missouri Wine Country, and even on the bank of the Missouri River. Live like a local and book your stay within walking distance of quaint coffee shops, shopping, and dining. Discover a new home-away-of-home here in St. Charles. Each historic guest house has its own story, now it’s your chance to be a part of it.